I used to do this (before my server died). You can for example use this to bypass Proton’s free tier one user per account limit.
Basically it’s about correctly setting the wireguard’s AllowedIPs and DisallowedIPs. Your laptop wants to send everything through wireguard. Your home server wants to send everything through Proton (or Mullvad or aVPN) except the communication with your laptop.
(I did that by marking the packets from one VPN with fwmark and sending marked packets to the other but that is a dumb solution for such a simple problem.)
It’s funny that the headline frames it as “a big number” when in reality majority of users don’t know what database they’re using and probably don’t even know what a database is. Such polls aren’t useless but you always get skewed results towards the more technical population. They would have to create a poll inside the nextcloud webapp to get more balanced results.